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If successful, the villain flees to another open location or I win, as appropriate. If I succeed, the location is closed because I completed its requirement, but the villain does not flee.
Because the location contains the villain, the location actually remains open and all non-villain cards are banished. When you reveal the next card, all the effects trigger, including if it was a villain. I should attempt to temporarily close locations and then attempt to defeat the villain, just as if the villain were encountered in normal play.